Chemosensitization by STI571 targeting the platelet-derived growth factor/platelet-derived growth factor receptor-signaling pathway in the tumor progression and angiogenesis of gastric carcinoma
نویسندگان
چکیده
منابع مشابه
Blocking platelet-derived growth factor-D/platelet-derived growth factor receptor beta signaling inhibits human renal cell carcinoma progression in an orthotopic mouse model.
Renal cell carcinoma is a highly malignant and often fatal disease of the kidney. It is difficult to treat, often because metastases are common at the time of presentation. Platelet-derived growth factor-D (PDGF-D) is a newly discovered member of the PDGF family; its function in tumor progression is largely unknown. Here, we examined the expression level of PDGF-D in human renal cell carcinoma ...
متن کاملTargeting the platelet-derived growth factor receptor in antivascular therapy for human ovarian carcinoma.
PURPOSE We sought to determine whether blockade of platelet-derived growth factor receptor (PDGF-R) activation by oral administration of a PDGF-R tyrosine kinase inhibitor (STI571) alone or in combination with i.p. paclitaxel can inhibit the progression of tumors caused by human ovarian carcinoma cells growing in the peritoneal cavity of female nude mice. EXPERIMENTAL DESIGN In several differ...
متن کاملAntagonist STI571 through Induction of Apoptosis Tumors by the Platelet-derived Growth Factor Receptor Growth Inhibition of Dermatofibrosarcoma Protuberans
Dermatofibrosarcoma protuberans (DFSP) and giant cell fibroblastoma (GCF) are recurrent, infiltrative skin tumors that presently are treated with surgery. DFSP and GCF tumors are genetically characterized by chromosomal rearrangements fusing the collagen type Ia1 (COLIA1) gene to the platelet-derived growth factor B-chain (PDGFB) gene. It has been shown that the resulting COL1A1/PDGF-B fusion p...
متن کاملRegulation of Platelet-Derived Growth Factor Receptor Signaling and its Targeting in Cancer Therapy
Ma, H. 2015. Regulation of Platelet-Derived Growth Factor Receptor Signaling and its Targeting in Cancer Therapy. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1092. 64 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9220-5. Overactivity of platelet-derived growth factor receptor (PDGFR) is a frequent event in many types of solid tumors. Ther...
متن کاملClinicopathological significance of platelet-derived growth factor B, platelet-derived growth factor receptor-β, and E-cadherin expression in gastric carcinoma
AIM OF THE STUDY Platelet-derived growth factor B (PDGF-B), a vital growth factor which can induce angiogenesis and epithelial-mesenchymal transition (EMT), is important in the metastasis of many tumors. However, the roles of PDGF-B in gastric carcinoma are largely unknown. We investigated the correlation between PDGF-B, PDGFR-β and E-cadherin expression with the clinical features of gastric ca...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cancer
سال: 2005
ISSN: 0008-543X,1097-0142
DOI: 10.1002/cncr.20973